Design and Synthesis of Cyclic Mismatch-Binding Ligands (CMBLs) with Variable Linkers by Ring-Closing Metathesis and their Photophysical and DNA Repeat Binding Properties Sanjukta Mukherjee,* Chikara Dohno, Kazuhiko Nakatani* Chem Eur J 2017 … [Continue reading]
New articles are always exciting and in an effort to bring more visibility to the community we’re experimenting with a recurring series of posts featuring the literary achievements of metathesis practitioners. As with all experiments, there are some … [Continue reading]
Higman, C.S.; Rufh, S.A.; McDonald, R.; Fogg, D.E. “Synthesis and Dynamic Behavior of a Dimeric Ruthenium Benzylidene Complex Bearing a Truncated N-Heterocyclic Carbene Ligand” J. Organomet. Chem. 2017, Advance Article. DOI: … [Continue reading]
Ahmed, T.S.; Grubbs, R. H. “Fast-Initiating, Ruthenium-based Catalysts for Improved Activity in Highly E-Selective Cross Metathesis” J. Am. Chem. Soc., 2017, 139, 1532-1537. [10.1021/jacs.6b11330] A recent publication from the Grubbs’ group … [Continue reading]
Bird, G. H.; Mazzola, E.; Opoku-Nsiah, K.; Lammert, M. A.; Godes, M.; Neuberg, D. S.; Walensky, L. D. Nat. Chem. Biol. 2016, 12, 845. Stapled peptides are an application of olefin metathesis first demonstrated by Grubbs and Blackwell1 using … [Continue reading]
Jeschek, M.; Reuter, R.; Heinisch, T.; Trindler, C.; Klehr, J.; Panke, S.; Ward, T. R. Nature 2016, doi:10.1038/nature19114 As evidenced by the large body of work on click chemistry, bioorthogonal reactions that can be performed in live cells are … [Continue reading]
Historic Philadelphia, Pennsylvania is set to host the 252nd American Chemical Society National Meeting and Exposition from August 21-25, 2016. “Chemistry, of the People, by the People, for the People” is the inspirational theme for the event and … [Continue reading]
Wang, G.; Krische, M.J.. “Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis” J. Am. Chem. Soc. 2016, 138, 8088-8091. DOI: 10.1021/jacs.6b04917 Ruthenium metathesis catalysts are … [Continue reading]
Dornan, P. K.; Lee, D.; Grubbs, R. H. “Tandem Olefin Metathesis/Oxidative Cyclization: Synthesis of Tetrahydrofuran Diols from Simple Olefins.” J. Am. Chem. Soc. 2016, 138, 6372. DOI: 10.1021/jacs.6b02653 Here at ATM, we spend a lot of time … [Continue reading]
Johns, A. M.; Ahmed, T.S.; Jackson, B.W.; Grubbs, R. H.; Pederson, R.L. “High Trans Kinetic Selectivity in Ruthenium-Based Olefin Cross-Metathesis through Stereoretention” Org. Lett. 2016 18 772-775 [DOI: 10.1021/acs.orglett.6b00031] In recent … [Continue reading]
The American Chemical Society is set to host their 251st National Meeting and Exposition in beautiful, sunny San Diego, California from March 13 – 17, 2016. “Computers in Chemistry” is the overall theme of the event and, as always done here at All … [Continue reading]