Terpenes Go ROMPing Into New Materials

June 28, 2013

Grau, E.; Mecking, S. “Polyterpenes by ring opening metathesis polymerization of caryophyllene and humulene” Green Chemistry 2013, 15, 1112-1115  Polymers are an indispensable commodity within modern society found in all sectors of a consumer economy, such as: materials, pharmaceuticals and energy. Typically derived from non-renewable petroleum sources, polymers account for ~7% of the gas oil […]

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Fast Ring Closing Metathesis Reactions at Low Catalyst Loadings

May 30, 2013

Despite the huge advances in the area of olefin metathesis, better catalysts are still sought to increase the efficiency of ring closing metathesis (RCM) reactions and make them more applicable in industry1. Recently, several modified second-gen Grubbs-Hoveyda catalysts were prepared and tested for RCM by the Plenio group. The goal was to develop faster initiating […]

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Lubricating Joints with Ring-opening Metathesis Polymerization

April 24, 2013

Wathier, M.; Lakin, B. A.; Bansal, P. N.; Stoddart, S. S.; Snyder, B. D.; Grinstaff, M. W. “A Large-Molecular-Weight Polyanion, Synthesized via Ring-Opening Metathesis Polymerization, as a Lubricant for Human Articular Cartilage” J. Am. Chem. Soc. 2013, 135, 4930–4933 Mammals use natural lubricants, known as synovial fluid to keep their joints moving smoothly. With age, […]

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Olefin Metathesis at the 245th ACS Meeting

March 21, 2013

The 245th ACS National Meeting & Exhibition is right around the corner and will be held in New Orleans, Louisiana from April 7-11, 2013. I guess it’s somewhat fitting that I happen to be writing this post on Fat Tuesday…#MardiGras! The theme of the spring meeting, “Chemistry of Energy & Food,” is fitting for New […]

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Light Illuminates the Path to Metathesis

February 22, 2013

Khalimon, A.Y; Leitao, E.M.; Piers, W. E. “Photogeneration of a Phosphonium Alkylidene Olefin Metathesis Catalyst” Organometallics 2012, 31, 5634-5637. DOI: 10.1021/om3005965 Chemists are always searching for a finely tunable, robust catalyst. Often this is accomplished by the use of some type of external activation that not only allows control over the activation of the catalyst, […]

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Macrocycles in Medicine: Vaniprevir (MK-7009)

January 9, 2013

Kong, J.; Chen; C.; Balsells-Padros; J., Cao, Y.; Dunn, R. F.; Dolman, S. J.; Janey, J.; Li, H.; and Zakuto, M.J. “Synthesis of the HCV Protease Inhibitor Vaniprevir (MK-7009) Using Ring-Closing Metathesis Reaction” J. Org. Chem. 2012, 77, 3820. Several years ago the chemical development group at Boehringer Ingelheim1 used a ring closing metathesis (RCM) step […]

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Using Isomerizing Metathesis to Access New Chemicals from Fatty Acids

December 12, 2012

Ohlmann, D. M.; Tschauder, N.; Stockis, J.-P.; Gooßen, Dierker, M.; Gooßen, L. J. “Isomerizing Olefin Metathesis as a Strategy To Access Defined Distributions of Unsaturated Compounds from Fatty Acids” J. Am. Chem. Soc. 2012, 134, 13716-13729. As petrochemical feedstocks are depleted, the chemical community is charged with discovering and developing new methods to access value […]

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