Jeschek, M.; Reuter, R.; Heinisch, T.; Trindler, C.; Klehr, J.; Panke, S.; Ward, T. R. Nature 2016, doi:10.1038/nature19114 As evidenced by the large body of work on click chemistry, bioorthogonal reactions that can be performed in live cells are … [Continue reading]
Historic Philadelphia, Pennsylvania is set to host the 252nd American Chemical Society National Meeting and Exposition from August 21-25, 2016. “Chemistry, of the People, by the People, for the People” is the inspirational theme for the event and … [Continue reading]
Wang, G.; Krische, M.J.. “Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis” J. Am. Chem. Soc. 2016, 138, 8088-8091. DOI: 10.1021/jacs.6b04917 Ruthenium metathesis catalysts are … [Continue reading]
Dornan, P. K.; Lee, D.; Grubbs, R. H. “Tandem Olefin Metathesis/Oxidative Cyclization: Synthesis of Tetrahydrofuran Diols from Simple Olefins.” J. Am. Chem. Soc. 2016, 138, 6372. DOI: 10.1021/jacs.6b02653 Here at ATM, we spend a lot of time … [Continue reading]
Johns, A. M.; Ahmed, T.S.; Jackson, B.W.; Grubbs, R. H.; Pederson, R.L. “High Trans Kinetic Selectivity in Ruthenium-Based Olefin Cross-Metathesis through Stereoretention” Org. Lett. 2016 18 772-775 [DOI: 10.1021/acs.orglett.6b00031] In recent … [Continue reading]
The American Chemical Society is set to host their 251st National Meeting and Exposition in beautiful, sunny San Diego, California from March 13 – 17, 2016. “Computers in Chemistry” is the overall theme of the event and, as always done here at All … [Continue reading]
Martinez, H.; Zhang, J.; Kobayashi, S.; Xu, Y.; Pitet, L. M.; Matta, M. E.; Hillmyer, M. A. “Functionalized Regio-regular Linear Polyethylenes from the ROMP of 3-Substituted Cyclooctenes” Appl. Petrochem Res., 2015, 5, 19–25. It turns out that … [Continue reading]
Denard, C. A.; Bartlett, M. J.; Wang, Y.; Lu, L.; Hartwig, J. F.; and Zhao, H. “Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides” ACS Catal., … [Continue reading]
William, A.D; Lee, A. C.-H. “Acid Mediated Ring Closing Metathesis: A Powerful Synthetic Tool Enabling the Synthesis of Clinical Stage Kinase Inhibitors” CHIMIA 2015, 69, 142-145 There’s an adage in total synthesis that “every nitrogen in a … [Continue reading]
Ireland, B. J.; Dobigny, B. T.; Fogg, D. E. “Decomposition of a Phosphine-Free Metathesis Catalyst by Amines and Other Bronsted Bases: Metallacyclobutane Deprotonation as a Major Deactivation Pathway” ACS Catal. 2015 5 (8) 4690-4698 [DOI: … [Continue reading]
García-Loma, R.; Albéniz, A. C. “Poly(w-bromoalkylnorbornenes-co-norbornene) by ROMP-Hydrogenation: a Robust Support Amenable to Post-Polymerization Functionalization” RSC Adv. 2015, 5, 70244. Introducing functionality into a polymer is often … [Continue reading]