Lubricating Joints with Ring-opening Metathesis Polymerization

April 24, 2013

Wathier, M.; Lakin, B. A.; Bansal, P. N.; Stoddart, S. S.; Snyder, B. D.; Grinstaff, M. W. “A Large-Molecular-Weight Polyanion, Synthesized via Ring-Opening Metathesis Polymerization, as a Lubricant for Human Articular Cartilage” J. Am. Chem. Soc. 2013, 135, 4930–4933 Mammals use natural lubricants, known as synovial fluid to keep their joints moving smoothly. With age, […]

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Olefin Metathesis at the 245th ACS Meeting

March 21, 2013

The 245th ACS National Meeting & Exhibition is right around the corner and will be held in New Orleans, Louisiana from April 7-11, 2013. I guess it’s somewhat fitting that I happen to be writing this post on Fat Tuesday…#MardiGras! The theme of the spring meeting, “Chemistry of Energy & Food,” is fitting for New […]

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Light Illuminates the Path to Metathesis

February 22, 2013

Khalimon, A.Y; Leitao, E.M.; Piers, W. E. “Photogeneration of a Phosphonium Alkylidene Olefin Metathesis Catalyst” Organometallics 2012, 31, 5634-5637. DOI: 10.1021/om3005965 Chemists are always searching for a finely tunable, robust catalyst. Often this is accomplished by the use of some type of external activation that not only allows control over the activation of the catalyst, […]

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Macrocycles in Medicine: Vaniprevir (MK-7009)

January 9, 2013

Kong, J.; Chen; C.; Balsells-Padros; J., Cao, Y.; Dunn, R. F.; Dolman, S. J.; Janey, J.; Li, H.; and Zakuto, M.J. “Synthesis of the HCV Protease Inhibitor Vaniprevir (MK-7009) Using Ring-Closing Metathesis Reaction” J. Org. Chem. 2012, 77, 3820. Several years ago the chemical development group at Boehringer Ingelheim1 used a ring closing metathesis (RCM) step […]

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Using Isomerizing Metathesis to Access New Chemicals from Fatty Acids

December 12, 2012

Ohlmann, D. M.; Tschauder, N.; Stockis, J.-P.; Gooßen, Dierker, M.; Gooßen, L. J. “Isomerizing Olefin Metathesis as a Strategy To Access Defined Distributions of Unsaturated Compounds from Fatty Acids” J. Am. Chem. Soc. 2012, 134, 13716-13729. As petrochemical feedstocks are depleted, the chemical community is charged with discovering and developing new methods to access value […]

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A Little Metathesis Catalyst Goes a Long Way

November 15, 2012

Amakawa, K.; Wrabetz, S.; Kröhnert, J.; Tzolova-Müller, G. Schlögl, R.; Trunschke, A. “In Situ Generation of Active Sites in Olefin Metathesis” J. Am. Chem. Soc. 2012, 134, 11462-11473. Heterogeneous, silica-supported tungsten catalysts are used to conduct the most efficient and largest practiced metathesis reactions in industry (The Phillips Triolefin Process). Despite their prominence, these catalysts […]

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Synergy Designed in the Molecular Framework of a Metathesis Monomer

October 31, 2012

Park, Hyeon; Choi, Tae-Lim. “Fast Tandem Ring-Opening/Ring-Closing Metathesis Polymerization from a Monomer Containing Cyclohexene and Terminal Alkyne” J. Am. Chem. Soc. 2012, 134 (17), 7270-7273. DOI: 10.1021/ja3017335 Sometimes two wrongs can make a right. Tae-Lim Choi and his group at Seoul National University have designed a monomer, which embodies this phrase by using  two unsuitable […]

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