Olefin Metathesis at 246th ACS Meeting

The American Chemical Society 246th National Meeting & Exhibition will take place this year from Sept 8-12 in Indianapolis, IN. As one might expect, given the location, the theme of the meeting is “Chemistry in Motion.” Although I didn’t see any … [Continue reading]

Terpenes Go ROMPing Into New Materials

Examples of terpenes used in metathesis

Grau, E.; Mecking, S. “Polyterpenes by ring opening metathesis polymerization of caryophyllene and humulene” Green Chemistry 2013, 15, 1112-1115  Polymers are an indispensable commodity within modern society found in all sectors of a consumer … [Continue reading]

Olefin Metathesis at the 245th ACS Meeting

The 245th ACS National Meeting & Exhibition is right around the corner and will be held in New Orleans, Louisiana from April 7-11, 2013. I guess it’s somewhat fitting that I happen to be writing this post on Fat Tuesday...#MardiGras! The theme of … [Continue reading]

Light Illuminates the Path to Metathesis

Scheme 1

Khalimon, A.Y; Leitao, E.M.; Piers, W. E. “Photogeneration of a Phosphonium Alkylidene Olefin Metathesis Catalyst” Organometallics 2012, 31, 5634-5637. DOI: 10.1021/om3005965 Chemists are always searching for a finely tunable, robust catalyst. … [Continue reading]

Macrocycles in Medicine: Vaniprevir (MK-7009)

Merk

Kong, J.; Chen; C.; Balsells-Padros; J., Cao, Y.; Dunn, R. F.; Dolman, S. J.; Janey, J.; Li, H.; and Zakuto, M.J. “Synthesis of the HCV Protease Inhibitor Vaniprevir (MK-7009) Using Ring-Closing Metathesis Reaction” J. Org. Chem. 2012, 77, … [Continue reading]