Comments on: About http://allthingsmetathesis.com Mon, 26 Jul 2010 19:44:02 -0700 http://wordpress.org/?v=2.8.4 hourly 1 By: nickel http://allthingsmetathesis.com/about/comment-page-1/#comment-144 nickel Wed, 17 Feb 2010 21:57:31 +0000 http://allthingsmetathesis.com/?page_id=2#comment-144 Chris, I haven't come across a report of if/how metathesis catalysts interfere with bioassays. If you find one, let me know! Chris,
I haven’t come across a report of if/how metathesis catalysts interfere with bioassays. If you find one, let me know!

]]> By: Chris D http://allthingsmetathesis.com/about/comment-page-1/#comment-135 Chris D Fri, 12 Feb 2010 16:53:50 +0000 http://allthingsmetathesis.com/?page_id=2#comment-135 Hi folks, Great job on this blog. Your posts are nicely written and cut to the chase to present some important observations. One item of interest to me: Are you aware of any studies/reports on the effects of Ru (e.g. metathesis catalysts or their byproducts) in various bioassays-- either in-vitro or cell-based screens? It's not something I worry about too much, but it would be nice to have some definitive answers for people, particularly with regards to cellular toxicity. Thanks! Hi folks,

Great job on this blog. Your posts are nicely written and cut to the chase to present some important observations.

One item of interest to me: Are you aware of any studies/reports on the effects of Ru (e.g. metathesis catalysts or their byproducts) in various bioassays– either in-vitro or cell-based screens? It’s not something I worry about too much, but it would be nice to have some definitive answers for people, particularly with regards to cellular toxicity.

Thanks!

]]> By: nickel http://allthingsmetathesis.com/about/comment-page-1/#comment-116 nickel Sat, 06 Feb 2010 20:13:34 +0000 http://allthingsmetathesis.com/?page_id=2#comment-116 One of the substrates is better classified as a Type II olefin due to the secondary allylic OTBS group, so the good selectivity isn't too surprising. But the rate of catalyst addition is curious indeed. It's also interesting that "bulk" DCM is a better solvent than DCM that was purified with an alumina purification system. Any thoughts as to why? One of the substrates is better classified as a Type II olefin due to the secondary allylic OTBS group, so the good selectivity isn’t too surprising. But the rate of catalyst addition is curious indeed. It’s also interesting that “bulk” DCM is a better solvent than DCM that was purified with an alumina purification system. Any thoughts as to why?

]]> By: Chris Thomas http://allthingsmetathesis.com/about/comment-page-1/#comment-104 Chris Thomas Wed, 03 Feb 2010 17:53:41 +0000 http://allthingsmetathesis.com/?page_id=2#comment-104 Hey guys, I just saw this reaction come out in Organic Letters today. It's a Lawrence Williams paper, where it looks like he's metathesizing two Type-I olefins? The interesting thing is they run the reaction over 7 days, using altogether 5 mol% while adding in 5 mg portions (41 mg total) every 24 hours. I've never seen such a gradual addition before and wouldn't the catalyst die much faster than just 24 hours? Or having the small amount keep the catalyst turnover from decreasing, thus allowing metathesis to occur over the whole 24 hours? Chris Hey guys, I just saw this reaction come out in Organic Letters today. It’s a Lawrence Williams paper, where it looks like he’s metathesizing two Type-I olefins? The interesting thing is they run the reaction over 7 days, using altogether 5 mol% while adding in 5 mg portions (41 mg total) every 24 hours. I’ve never seen such a gradual addition before and wouldn’t the catalyst die much faster than just 24 hours? Or having the small amount keep the catalyst turnover from decreasing, thus allowing metathesis to occur over the whole 24 hours?

Chris

]]> By: nickel http://allthingsmetathesis.com/about/comment-page-1/#comment-31 nickel Tue, 24 Nov 2009 21:12:43 +0000 http://allthingsmetathesis.com/?page_id=2#comment-31 This is definitely an interesting phenomenon, Cezary, and is a good idea for a posting. A few examples have popped up the past couple of years where perfluorinated solvents show advantages, and to my knowledge no one has yet explained why. I'm glad to hear that the Grela group is working hard on this question! This is definitely an interesting phenomenon, Cezary, and is a good idea for a posting. A few examples have popped up the past couple of years where perfluorinated solvents show advantages, and to my knowledge no one has yet explained why. I’m glad to hear that the Grela group is working hard on this question!

]]> By: Cezary Samojlowicz http://allthingsmetathesis.com/about/comment-page-1/#comment-29 Cezary Samojlowicz Fri, 20 Nov 2009 13:44:46 +0000 http://allthingsmetathesis.com/?page_id=2#comment-29 I would like to suggest a new topic about Fluorinated Aromatic Hydrocarbons. In 2007 we found that reaction performed in such fluorinated solvents (eg. hexafluorobenzene) improved difficult metathesis reactions. http://www.rsc.org/publishing/journals/CC/article.asp?doi=B816567J Currently we are working on explanation this phenomena. It is not that easy. I would appreciate put a new topic about Fluorinated solvents on your website. People who working in olefin metathesis (and not only) could give some nice hints and comments about this unprecedented phenomena. Best regards Cezary I would like to suggest a new topic about Fluorinated Aromatic Hydrocarbons.
In 2007 we found that reaction performed in such fluorinated solvents (eg. hexafluorobenzene) improved difficult metathesis reactions.
http://www.rsc.org/publishing/journals/CC/article.asp?doi=B816567J
Currently we are working on explanation this phenomena. It is not that easy.
I would appreciate put a new topic about Fluorinated solvents on your website.
People who working in olefin metathesis (and not only) could give some nice hints and comments about this unprecedented phenomena.

Best regards
Cezary

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