Comments on: About http://allthingsmetathesis.com Fri, 16 Dec 2011 20:21:47 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: Matt http://allthingsmetathesis.com/about/comment-page-1/#comment-3374 Matt Fri, 16 Dec 2011 20:21:47 +0000 http://allthingsmetathesis.com/?page_id=2#comment-3374 Thanks very much Daryl - I'll be sure to read those papers! Matt Thanks very much Daryl – I’ll be sure to read those papers!

Matt

]]> By: Daryl http://allthingsmetathesis.com/about/comment-page-1/#comment-3373 Daryl Fri, 16 Dec 2011 19:31:44 +0000 http://allthingsmetathesis.com/?page_id=2#comment-3373 Matt, Here are a few review articles to check out regarding solid-supported olefin metathesis catalysts: (1) Coperet, C.; Basset, J.-M. AdV. Synth. Catal. 2007, 349, 78–92. (2) Clavier, H.; Grela, K.; Kirschning, A.; Mauduit, M.; Nolan, S. P. Angew. Chem., Int. Ed. 2007, 46, 6786–6801. (3) Buchmeiser, M. R. Chem. Rev. 2009, 109, 303-321. Also, another great resource is the review article by Grubbs and Vougioukalakis: Chem. Rev. 2010, 110, 1746-1787. This is just a great review article in general, but specifically section 10 details some supported catalyst work. Also, feel free to check out a paper that a co-worker and I published with Grubbs a few years back: Org. Lett. 2009, 11, 1261-1264. Perhaps here at ATM, we should do a posting on some solid-supported catalyst work...look for that in 2012. Thanks for the interest Matt! Best of luck with your project! Daryl Matt,

Here are a few review articles to check out regarding solid-supported olefin metathesis catalysts:

(1) Coperet, C.; Basset, J.-M. AdV. Synth. Catal. 2007, 349, 78–92.
(2) Clavier, H.; Grela, K.; Kirschning, A.; Mauduit, M.; Nolan, S. P. Angew. Chem., Int. Ed. 2007, 46, 6786–6801.
(3) Buchmeiser, M. R. Chem. Rev. 2009, 109, 303-321.

Also, another great resource is the review article by Grubbs and Vougioukalakis:

Chem. Rev. 2010, 110, 1746-1787. This is just a great review article in general, but specifically section 10 details some supported catalyst work.

Also, feel free to check out a paper that a co-worker and I published with Grubbs a few years back:

Org. Lett. 2009, 11, 1261-1264.

Perhaps here at ATM, we should do a posting on some solid-supported catalyst work…look for that in 2012.

Thanks for the interest Matt! Best of luck with your project!

Daryl

]]> By: Matt http://allthingsmetathesis.com/about/comment-page-1/#comment-3288 Matt Fri, 09 Dec 2011 16:18:07 +0000 http://allthingsmetathesis.com/?page_id=2#comment-3288 Hello again to everyone at ATM. I put my RCM work to one side for a few months, but now I'm back on the attack to work on increasing yield through optimisation of work-up and isolation. One idea that occurred from my discussion is solid-supported ruthenium catalysts for RCM; has such an idea been entertained and investigated? I would assume it has been, but I can't seem to find anything in the literature (apart from examples where the substrate to be ring-closed is tethered to a solid support!) I'm open to email discussion on this! Matt p.s. merry christmas Hello again to everyone at ATM.

I put my RCM work to one side for a few months, but now I’m back on the attack to work on increasing yield through optimisation of work-up and isolation. One idea that occurred from my discussion is solid-supported ruthenium catalysts for RCM; has such an idea been entertained and investigated? I would assume it has been, but I can’t seem to find anything in the literature (apart from examples where the substrate to be ring-closed is tethered to a solid support!)

I’m open to email discussion on this!

Matt

p.s. merry christmas

]]> By: nickel http://allthingsmetathesis.com/about/comment-page-1/#comment-2123 nickel Mon, 20 Jun 2011 19:47:23 +0000 http://allthingsmetathesis.com/?page_id=2#comment-2123 Much thanks, Matt! Much thanks, Matt!

]]> By: Matt http://allthingsmetathesis.com/about/comment-page-1/#comment-2121 Matt Sun, 19 Jun 2011 18:13:05 +0000 http://allthingsmetathesis.com/?page_id=2#comment-2121 Hi guys, Nothing much to add in the way of interesting questions that you might be able to investigate, but I just wanted to let you know I've found this website a really good and strong resource of information for my work into RCM; not just as a collection of literature, but also as a source of practical information. Also, in general I find the articles all to be enthusiastically written - metathesis certainly is an exciting area to be involved in! Regards, Matt Hi guys,

Nothing much to add in the way of interesting questions that you might be able to investigate, but I just wanted to let you know I’ve found this website a really good and strong resource of information for my work into RCM; not just as a collection of literature, but also as a source of practical information. Also, in general I find the articles all to be enthusiastically written – metathesis certainly is an exciting area to be involved in!

Regards,

Matt

]]> By: milkshake http://allthingsmetathesis.com/about/comment-page-1/#comment-1310 milkshake Fri, 18 Feb 2011 15:40:52 +0000 http://allthingsmetathesis.com/?page_id=2#comment-1310 Andy, please can you drop me an e-mail, I have a chemistry job-related question. Best, Tomas Andy, please can you drop me an e-mail, I have a chemistry job-related question.
Best, Tomas

]]> By: nickel http://allthingsmetathesis.com/about/comment-page-1/#comment-144 nickel Wed, 17 Feb 2010 21:57:31 +0000 http://allthingsmetathesis.com/?page_id=2#comment-144 Chris, I haven't come across a report of if/how metathesis catalysts interfere with bioassays. If you find one, let me know! Chris,
I haven’t come across a report of if/how metathesis catalysts interfere with bioassays. If you find one, let me know!

]]> By: Chris D http://allthingsmetathesis.com/about/comment-page-1/#comment-135 Chris D Fri, 12 Feb 2010 16:53:50 +0000 http://allthingsmetathesis.com/?page_id=2#comment-135 Hi folks, Great job on this blog. Your posts are nicely written and cut to the chase to present some important observations. One item of interest to me: Are you aware of any studies/reports on the effects of Ru (e.g. metathesis catalysts or their byproducts) in various bioassays-- either in-vitro or cell-based screens? It's not something I worry about too much, but it would be nice to have some definitive answers for people, particularly with regards to cellular toxicity. Thanks! Hi folks,

Great job on this blog. Your posts are nicely written and cut to the chase to present some important observations.

One item of interest to me: Are you aware of any studies/reports on the effects of Ru (e.g. metathesis catalysts or their byproducts) in various bioassays– either in-vitro or cell-based screens? It’s not something I worry about too much, but it would be nice to have some definitive answers for people, particularly with regards to cellular toxicity.

Thanks!

]]> By: nickel http://allthingsmetathesis.com/about/comment-page-1/#comment-116 nickel Sat, 06 Feb 2010 20:13:34 +0000 http://allthingsmetathesis.com/?page_id=2#comment-116 One of the substrates is better classified as a Type II olefin due to the secondary allylic OTBS group, so the good selectivity isn't too surprising. But the rate of catalyst addition is curious indeed. It's also interesting that "bulk" DCM is a better solvent than DCM that was purified with an alumina purification system. Any thoughts as to why? One of the substrates is better classified as a Type II olefin due to the secondary allylic OTBS group, so the good selectivity isn’t too surprising. But the rate of catalyst addition is curious indeed. It’s also interesting that “bulk” DCM is a better solvent than DCM that was purified with an alumina purification system. Any thoughts as to why?

]]> By: Chris Thomas http://allthingsmetathesis.com/about/comment-page-1/#comment-104 Chris Thomas Wed, 03 Feb 2010 17:53:41 +0000 http://allthingsmetathesis.com/?page_id=2#comment-104 Hey guys, I just saw this reaction come out in Organic Letters today. It's a Lawrence Williams paper, where it looks like he's metathesizing two Type-I olefins? The interesting thing is they run the reaction over 7 days, using altogether 5 mol% while adding in 5 mg portions (41 mg total) every 24 hours. I've never seen such a gradual addition before and wouldn't the catalyst die much faster than just 24 hours? Or having the small amount keep the catalyst turnover from decreasing, thus allowing metathesis to occur over the whole 24 hours? Chris Hey guys, I just saw this reaction come out in Organic Letters today. It’s a Lawrence Williams paper, where it looks like he’s metathesizing two Type-I olefins? The interesting thing is they run the reaction over 7 days, using altogether 5 mol% while adding in 5 mg portions (41 mg total) every 24 hours. I’ve never seen such a gradual addition before and wouldn’t the catalyst die much faster than just 24 hours? Or having the small amount keep the catalyst turnover from decreasing, thus allowing metathesis to occur over the whole 24 hours?

Chris

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