Matt

Here are a few review articles to check out regarding solid-supported olefin metathesis catalysts:

(1) Coperet, C.; Basset, J.-M. AdV. Synth. Catal. 2007, 349, 78–92.
(2) Clavier, H.; Grela, K.; Kirschning, A.; Mauduit, M.; Nolan, S. P. Angew. Chem., Int. Ed. 2007, 46, 6786–6801.
(3) Buchmeiser, M. R. Chem. Rev. 2009, 109, 303-321.

Also, another great resource is the review article by Grubbs and Vougioukalakis:

Chem. Rev. 2010, 110, 1746-1787. This is just a great review article in general, but specifically section 10 details some supported catalyst work.

Also, feel free to check out a paper that a co-worker and I published with Grubbs a few years back:

Org. Lett. 2009, 11, 1261-1264.

Perhaps here at ATM, we should do a posting on some solid-supported catalyst work…look for that in 2012.

Thanks for the interest Matt! Best of luck with your project!

Daryl

I put my RCM work to one side for a few months, but now I’m back on the attack to work on increasing yield through optimisation of work-up and isolation. One idea that occurred from my discussion is solid-supported ruthenium catalysts for RCM; has such an idea been entertained and investigated? I would assume it has been, but I can’t seem to find anything in the literature (apart from examples where the substrate to be ring-closed is tethered to a solid support!)

I’m open to email discussion on this!

Matt

p.s. merry christmas

Nothing much to add in the way of interesting questions that you might be able to investigate, but I just wanted to let you know I’ve found this website a really good and strong resource of information for my work into RCM; not just as a collection of literature, but also as a source of practical information. Also, in general I find the articles all to be enthusiastically written – metathesis certainly is an exciting area to be involved in!

Regards,

Matt

Great job on this blog. Your posts are nicely written and cut to the chase to present some important observations.

One item of interest to me: Are you aware of any studies/reports on the effects of Ru (e.g. metathesis catalysts or their byproducts) in various bioassays– either in-vitro or cell-based screens? It’s not something I worry about too much, but it would be nice to have some definitive answers for people, particularly with regards to cellular toxicity.

Thanks!