Macrocycles in Medicine: Vaniprevir (MK-7009)

Kong, J.; Chen; C.; Balsells-Padros; J., Cao, Y.; Dunn, R. F.; Dolman, S. J.; Janey, J.; Li, H.; and Zakuto, M.J. “Synthesis of the HCV Protease Inhibitor Vaniprevir (MK-7009) Using Ring-Closing Metathesis Reaction” J. Org. Chem. 2012, 77, 3820. Several years ago the chemical development group at Boehringer Ingelheim1 used a ring closing metathesis (RCM) step […]