Ruthenacyclobutanes and Productive versus Degenerate Metathesis Events

Keitz, B. K.; Grubbs, R. H.  “Probing the Origin of Degenerate Metathesis Selectivity via Characterization and Dynamics of Ruthenacyclobutanes Containing Variable NHCs.”  J. Am. Chem. Soc., 2011, 133 (40), 16277-16284. Back in September of 2010, ATM’s very own Andy Nickel wrote a post on a publication from the Grubbs group describing non-productive events during ring-closing […]

Biological Properties of Grubbs and Hoveyda-Grubbs Catalysts

Oehninger, L., Alborzinia, H., Ludewig, S., Baumann, K., Wölfl, S. and Ott, I. (2011), From Catalysts to Bioactive Organometallics: Do Grubbs Catalysts Trigger Biological Effects?. ChemMedChem. doi: 10.1002/cmdc.201100308 Organometallic compounds are primarily used in catalysis, however, some of them have been found to have important biological properties as well. In the early 60s’, the discovery […]

Acrylonitrile Cross-Metathesis

Miao, X.; Dixneuf, P.H.; Fischmeister, C.; Bruneau, C. “A green route to nitrogen-containing groups: the acrylonitrile cross-metathesis and applications to plant oil derivatives.” Green Chem., 2011, 13, 2258-2271. A straightforward route to organonitriles, versatile intermediates in organic synthesis, would be cross metathesis (CM) with acrylonitrile. Unfortunately, acrylonitrile is definitely not the best substrate for metathesis reactions. […]