Olefin Metathesis Reactions in Total Synthesis

Fürstner, A. Metathesis in total synthesis. Chem. Commun., 2011, 47, 6505-6511 The subject of olefin metathesis reactions in total synthesis has been reviewed numerous times including a book published last year. The huge impact of olefin metathesis in this area is not surprising. It’s a catalytic transformation which forms and cleaves C-C bonds at the […]

Making Cyclic Alkenyl Bromides

Gatti, M.; Drinkel, E.; Wu, L. Wang, Pusterla, I.; Gaggia, F.; Dorta, R. Efficient Ring-Closing Metathesis of Alkenyl Bromides: The Importance of Protecting the Catalyst during the Olefin Approach. J. Am. Chem. Soc. 2010, 132, 15179 – 15181. Cyclic alkenyl halides (especially bromides) are desirable synthons in organic synthesis because they can be further derivatized […]