Low Metathesis Catalyst Loadings with Ethyl Acrylate

Cross metathesis using Grubbs Catalysts is basically “dump and stir” chemistry, which means that you can generally make your target compound the first time you try. If you browse through the literature, you’ll see plenty of examples of successful reactions using Grubbs Catalysts, but most of these use >1 mol% of catalyst. This is fine if […]

Alternating Copolymerization and Stereoselectivity in ROMP

Torker, S.; Müller, A.; Chen, P. “Building Stereoselectivity into a Chemoselective Ring-Opening Metathesis Polymerization Catalyst for Alternating Copolymerization.” Angew. Chem. Int. Ed. 2010, 49, 3762-3766.  A recent report from the Peter Chen group presents a series of elegant investigations that highlight factors that influence the chemoselectivity and stereoselectivity of metathesis polymerizations. Through careful study of […]