Stapled Peptides Via Olefin Metathesis

In scanning the “Metathesis in Action” section of All Things Metathesis, one will come across a number of posts that discuss the use of ring-closing metathesis (RCM) for the construction of a variety of small molecule targets that are of interest in the pharmaceutical industry. Another area within the pharmaceutical sciences that has yet to be […]

New User Friendly Alkyne Metathesis Catalysts

An efficient total synthesis of the antiproliferative macrolide and cell migration inhibitor lactidomycin relying on ring-closing alkyne metathesis was published recently by the Fürstner group. Lactidomycin contains a very strained 12-membered lactone which incorporates seven sp2-carbon atoms. If that’s not enough, the authors opted for an intermediate which is even more strained than the final […]