Catalysts for Asymmetric Olefin Metathesis

When it comes to asymmetric olefin metathesis, molybdenum catalysts are generally better than their ruthenium homologues. However, chiral ruthenium metathesis catalysts have also been designed for asymmetric metathesis, with some success. Two main examples are the C2 symmetric catalyst 1 developed by Grubbs and the Hoveyda complex 2 featuring a bidentate ligand.1,2 Building upon those […]

Cross Metathesis and Oligosaccharides

Schürer, S. C.; Blechert, S. Chem. Commun., 1999, 1203–1204. Macrocycles and linear unsaturated compounds are not the only molecules constructed using the power of metathesis. Oligosaccharides benefit from metathesis too! One of the goals in proteomics research is to understand the functional impact of post-translational modification, and protein glycosylation represents the most complex post-translational event. […]

Acyclic Diaminocarbene Olefin Metathesis Catalysts

Rosen, E. L.; Sung, D. H.; Chen, Z.; Lynch, V. M.; Bielawski, C. W. Olefin Metathesis Catalysts Containing Acyclic Diaminocarbenes Organometallics, 2010, 29, 250. As the collection of functional group tolerant olefin metathesis catalysts continues to grow, a basic recipe has predominated catalyst design:  ruthenium, an alkylidene, Lewis basic donor ligands (e.g. phosphines, N-heterocyclic carbenes […]