Heteroaromatics by Olefin Metathesis

Over the past few years, Timothy Donohoe’s group at the University of Oxford has been thinking up new ways to make heteroaromatics using ring closing metathesis.1,2 They recently came up with a slick way to prepare substituted furans using cross-metathesis as well.3 There are no other reports on using cross metathesis for the construction of […]

Everything (or almost) about the 2nd Generation Grubbs Catalysts

Samojłowicz, C.; Bieniek, M.; Grela, K. Ruthenium-based olefin metathesis catalysts bearing N-heterocyclic carbene ligands, Chem. Rev. 2009, 109, 3708 – 3742. Vougioukalakis, G. C.; Grubbs, R. H. Ruthenium-based heterocyclic carbene-coordinated olefin metathesis catalysts, Chem. Rev. 2010, 110, 1746 – 1787. For metathesis, the 00’s was the decade of the second generation ruthenium catalysts. Besides the […]

Grubbs Talks Olefin Metathesis with the Scientists of Tomorrow

Last month Nobel Laureate Robert Grubbs visited the University of Minnesota for a two-day series of lectures and student interviews. The event was part of the Honeywell-Nobel Initiative Lecture Series which is designed to link one generation of leading scientists with the development of the next, by establishing a forum for students to learn from […]

Field Guide to Precision End-group Functionalization

Hilf, S.; Kilbinger, A.F.M. Functional end groups for polymers prepared using ring-opening metathesis polymerization, Nature Chemistry 1, 537 – 546 (2009) End-group modification of polymer and oligomer structures is a powerful tool for a diverse range of applications. Living ROMP polymerizations are well-suited for this type of precise end-group manipulation, but the strategy for functionalization […]