All Things Metathesis

ASAP’s – 2017 – Week 32

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Iodine-mediated rearrangements of diallylsilanes
Gregory W. O’Neil,* Elizabeth J. Cummins
Tet Lett 2017 58 3406-3409

Total synthesis of greensporone C
Kwanruthai Tadpetch,* Laksamee Jeanmard, Vatcharin Rukachaisirikul
Tet Lett 2017 58 3453-3456

A Highly Stereoselective and Efficient Catalytic Approach for the Synthesis of trans-Stilbene–Arenes as π-Conjugated Materials
Mariusz Majchrzak,* Grzegorz Wilkowski, and Maciej Kubicki
Eur J Org Chem 2017 ASAP

Cascade Polymerization via Controlled Tandem Olefin Metathesis/Metallotropic 1,3-Shift Reactions for the Synthesis of Fully Conjugated Polyenynes
Cheol Kang, Hyeon Park, Jin-Kyung Lee, and Tae-Lim Choi*
J Am Chem Soc 2017 ASAP

Palladium-Catalyzed Allylic Amination: A Powerful Tool for the Enantioselective Synthesis of Acyclic Nucleoside Phosphonates
Mariam Azzouz, Sébastien Soriano, Margarita Escudero-Casao, M. Isabel Matheu, Sergio Castillón,* and Yolanda Díaz*
Org Biomol Chem 2017 ASAP

ASAP’s – 2017 – Week 31

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Design and Synthesis of Cyclic Mismatch-Binding Ligands (CMBLs) with Variable Linkers by Ring-Closing Metathesis and their Photophysical and DNA Repeat Binding Properties Sanjukta Mukherjee,* Chikara Dohno, Kazuhiko Nakatani* Chem Eur J 2017 … [Continue reading]

ASAP’s – 2017 – Week 30

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New articles are always exciting and in an effort to bring more visibility to the community we’re experimenting with a recurring series of posts featuring the literary achievements of metathesis practitioners. As with all experiments, there are some … [Continue reading]

Not Alone – Formation of a Ruthenium Dimer

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Higman, C.S.; Rufh, S.A.; McDonald, R.; Fogg, D.E. “Synthesis and Dynamic Behavior of a Dimeric Ruthenium Benzylidene Complex Bearing a Truncated N-Heterocyclic Carbene Ligand” J. Organomet. Chem. 2017, Advance Article. DOI: … [Continue reading]

Stapled Peptides – Getting into the Cell

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Bird, G. H.; Mazzola, E.; Opoku-Nsiah, K.; Lammert, M. A.; Godes, M.; Neuberg, D. S.; Walensky, L. D. Nat. Chem. Biol. 2016, 12, 845. Stapled peptides are an application of olefin metathesis first demonstrated by Grubbs and Blackwell1 using … [Continue reading]

In Vivo Metathesis Using an Artificial Metalloenzyme

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Jeschek, M.; Reuter, R.; Heinisch, T.; Trindler, C.; Klehr, J.; Panke, S.; Ward, T. R. Nature 2016, doi:10.1038/nature19114 As evidenced by the large body of work on click chemistry, bioorthogonal reactions that can be performed in live cells are … [Continue reading]

Olefin Metathesis at the 252nd ACS Meeting

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Historic Philadelphia, Pennsylvania is set to host the 252nd American Chemical Society National Meeting and Exposition from August 21-25, 2016.  “Chemistry, of the People, by the People, for the People” is the inspirational theme for the event and … [Continue reading]

Stereoretentive Olefin Metathesis

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Johns, A. M.; Ahmed, T.S.; Jackson, B.W.; Grubbs, R. H.; Pederson, R.L. “High Trans Kinetic Selectivity in Ruthenium-Based Olefin Cross-Metathesis through Stereoretention” Org. Lett. 2016 18 772-775 [DOI: 10.1021/acs.orglett.6b00031] In recent … [Continue reading]